West Precinct detectives uncovered copious amounts of drugs and cash at a short-term rental south of downtown on Friday.
Police say 74 pounds of marijuana and $71,000 in cash were found at the home on Tuggle Ave.
Officials estimate the street value of the drugs is around $250,000.
Detectives also uncovered a hand-drawn flow chart from the residence that they believe may represent a distribution chain.
Three men from California were arrested in the bust.
Bruce Malmsted, 34, of San Diego, Fred Ferguson, 38, of Vallejo; and Ricky Ware, 34, of Sacramento, were taken into custody and charged with felony marijuana charges.
Malmstead was jailed in lieu of a $76,000 bond. Bail for Ferguson and Ware was set at $77,000.
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