Tennessee is the No. 1 seed in the Louisville Regional. The Lady Vols, who are the only team to have played in every NCAA tournament, will open up against Northwestern State on Saturday.
Tennessee is trying to end a five-year drought of not making it to the Final Four - the longest such streak in school history.
The Lady Vols, who won the SEC tournament, won't have an easy path to the Final Four. West Virginia is the second seed. Host Louisville is the three seed and Maryland is the four.
The Cardinals knocked off top-seed Baylor in the regional semifinals last season before beating Tennessee to earn a trip to the Final Four. Now they could get a similar opportunity against the Lady Vols on their home floor.
The Vanderbilt Commodores are also going to the show, making their 15th straight NCAA tournament appearance.
The Commodores will play in Toledo against Arizona State, and the winner would likely face top-seeded Notre Dame.
And there's more happiness in Murfreesboro. The MTSU Lady Raiders are back in the tournament for the 17th time in school history.
But, despite winning the conference tournament and regular season title, Middle Tennessee is eight seed and will play Oregon State in Seattle.
If the Lady Raiders win that one, top-seeded South Carolina would likely be next up.
Copyright 2014 WSMV (Meredith Corporation). All rights reserved. The Associated Press contributed to this report.
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